Carolina Bongini and colleagues analyze the prevalence and clinical correlates of atrial fibrillation (AF) in relation to genotype in a large hypertrophic cardiomyopathy(HC) cohort. They concluded that, in patients with HC, genetic testing cannot be used in clinical decision making with regard to management strategies for AF, genotype is not predictive of onset or severity of AF, and exceptions are represented by rare genes suggesting specific molecular pathways for AF in genetic cardiomyopathies.
Bongini, Carolina et al. The American Journal of Cardiology.
"Alamut is the best tool I have used for the annotation of DNA variants. It has a great user interface, combines data from multiple sources and allows for ease of variant interpretation by clinical geneticists."
JORDAN LERNER-ELLIS, Ph.D.
Mt. Sinai Hospital, Toronto