Lars Jønson and colleagues perform a next-generation sequencing analysis to evaluate the frequency of pathogenic RAD51C mutations identified in Danish breast and/or ovarian cancer families. They show that pathogenic RAD51C mutations were identified in 0.5 % of Danish families with increased risk of hereditary breast and/or ovarian cancer and suggest that RAD51C should be included in gene panel testing of individuals with high risk of breast and ovarian cancer.
Jønson, Lars et al. Breast Cancer Research and Treatment.
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The Jackson Laboratory, Farmington