Richarda Voer and colleagues report a study on novel candidate genes for colorectal cancer (CRC) at an early age in life. They applied a strategy for seraching genes with multiple rare (minor allele frequency <0.001) variants in cases but not in controls with a potentially damaging effect. They identified LRP6 and PTPN12 as novel candidate genes for CRC susceptibility.
Voer, Richarda M. de et al. PLOS Genet.
"I recommend Alamut to all of my colleagues and friends in genomics!"
EDGARDO R. PARRILLA, MD
Duke University, Durham, USA